What does this research mean for the field?

Ischemic preconditioning reduces interstitial and vascular adenosine levels during ischemia-reperfusion and improves functional recovery independently of metabolic changes during the ischemic insult. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1998Cardiovascular ResearchOpen Access

Extracellular adenosine levels and cellular energy metabolism in ischemically preconditioned rat heart

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Why the study?

Does ischemic preconditioning alter extracellular adenosine levels and cellular energy metabolism in Langendorff perfused rat hearts?

Population

Langendorff perfused rat hearts (n=23 total: 9 control, 6 preconditioned, 8 repetitive ischemia-reperfusion)

Comparison

Ischemic preconditioning or repetitive… vs Control hearts undergoing 30 min of global…

Design

Preclinical

Follow-up

30 min reperfusion

Authors

GHGlenn HarrisonGriffith University RWRoger J. WillisGriffith University JHJohn P. HeadrickGriffith University

Discussion

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Implication

Ischemic preconditioning may reduce adenosine in isolated rat hearts; leaves open its mechanistic role and precludes clinical translation.

Structured PICO

Does ischemic preconditioning alter extracellular adenosine levels and cellular energy metabolism in Langendorff perfused rat hearts?

Population

Langendorff perfused rat hearts (n=23 total: 9 control, 6 preconditioned, 8 repetitive ischemia-reperfusion)

Intervention

Ischemic preconditioning (5 min ischemic episode and 10 min reflow prior to 30 min ischemia and 30 min reperfusion) or repetitive ischemia-reperfusion (3 x 5 min ischemic episodes)

Comparator

Control hearts undergoing 30 min of global normothermic ischemia and 30 min reperfusion without preconditioning

Outcome

Extracellular adenosine levels (interstitial fluid and venous effluent) and cellular energy metabolism (intracellular ATP, PCr, Pi, H+, free Mg2+) measured by microdialysis and 31P-NMR spectroscopy, and functional recoverysurrogate

Ischemic preconditioning reduces interstitial and vascular adenosine levels during ischemia-reperfusion and improves functional recovery, which appears unrelated to metabolic changes during the ischemic insult.

Cite This Study

Harrison et al. (1998) studied this question.

synapsesocial.com/papers/6a1e85508a8a69122355fca9 https://doi.org/10.1016/s0008-6363(98)00123-0

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Implication

Ischemic preconditioning may reduce adenosine in isolated rat hearts; leaves open its mechanistic role and precludes clinical translation.

Extracellular adenosine levels and cellular energy metabolism in ischemically preconditioned rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Extracellular adenosine levels and cellular energy metabolism in ischemically preconditioned rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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