Why the study?
Does preincubation with adenosine or adenosine agonists protect isolated rat cardiomyocytes from ischaemic cell death?
Population
Isolated rat cardiomyocytes
Comparison
Preincubation with adenosine, CCPA, or carbachol… vs Paired control preparations
Design
Preclinical
Authors
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Minimal protection in isolated myocytes; leaves open whether adenosine cardioprotection requires intact tissue or in vivo conditions.
Does preincubation with adenosine or adenosine agonists protect isolated rat cardiomyocytes from ischaemic cell death?
Adenosine and A1 selective agonists offer minimal, glucose-dependent protection against ischaemic injury in isolated rat cardiomyocytes, which does not fully explain the larger protection seen in intact hearts.
Ganote et al. (1993) studied this question.
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