Why the study?
Does the duration of ischemic preconditioning determine the involvement of adenosine A1 and A3 receptors in reducing infarct size in rats?
Population
Anesthetized rats undergoing 60-min coronary artery occlusion followed by 180 min of reperfusion
Comparison
Ischemic preconditioning with varying durations… vs Control rats without ischemic preconditioning
Design
Preclinical
Follow-up
180 min of reperfusion
Authors
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Longer IPC stimuli implicate A1/A3 receptors in rat infarct reduction; challenges brief-stimulus consensus and leaves clinical translation open.
Does the duration of ischemic preconditioning determine the involvement of adenosine A1 and A3 receptors in reducing infarct size in rats?
The involvement of adenosine A1 and A3 receptors in ischemic preconditioning in rat hearts depends critically on the duration of the preconditioning stimulus.
David Liem (2001) studied this question.
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