Why the study?
Does N6-cyclohexyladenosine (CHA) alter glycogen and glucose metabolism and improve mechanical function in ischaemic and post-ischaemic isolated working rat hearts?
Does N6-cyclohexyladenosine (CHA) alter glycogen and glucose metabolism and improve mechanical function in ischaemic and post-ischaemic isolated working rat hearts?
Adenosine A1 receptor stimulation with CHA improves post-ischaemic mechanical function in rat hearts, associated with stimulated glycogen synthesis and improved metabolic coupling during reperfusion.
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CHA may enhance reperfusion recovery via glycogen modulation in rat hearts; leaves open translation of A1 agonism to clinical cardioprotection.
Fraser et al. (1999) studied this question.
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