Population
Isolated, working guinea-pig hearts, perfused with glucose-fortified Krebs-Henseleit buffer
Comparison
Adenosine A1 receptor blockade with… vs Control (no adenosine receptor blockade)
Design
Preclinical
Follow-up
15 min mild hypoperfusion followed by 10 min ischaemia
Authors
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A1 blockade augments glycolysis in ischemic myocardium in animals; leaves open whether this translates to human metabolic therapy.
Endogenous adenosine attenuates anaerobic glycolysis in hypoperfused and ischemic myocardium by blunting phosphofructokinase activity via A1 receptors.
Zheng Gao (1997) studied this question.
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