Why the study?
Does endogenous adenosine mediate hypoxia-induced atrioventricular block in isolated guinea pig hearts?
Population
Isolated perfused guinea pig hearts
Comparison
Hypoxic perfusion and administration of… vs Infusion of adenosine plus dipyridamole under…
Design
Preclinical
Authors
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Endogenous adenosine may mediate hypoxic AV block in isolated hearts; hypothesis-generating for adenosine antagonists, with no clinical implications yet.
Does endogenous adenosine mediate hypoxia-induced atrioventricular block in isolated guinea pig hearts?
Endogenous adenosine release during hypoxia is sufficient to cause atrioventricular block, suggesting a potential therapeutic role for adenosine antagonists in treating AV block.
Wesley et al. (1986) studied this question.
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