Key result
Adenosine receptor activation recovers ischemic myocardial energy but does not fully drive postischemic contractile recovery.
Why the study?
Does interstitial adenosine mediate acute hibernation of guinea pig myocardium?
Population
Isolated working guinea pig hearts perfused with glucose fortified Krebs-Henseleit
Comparison
Ecto 5'-nucleotidase inhibitor… vs Untreated isolated working guinea pig hearts…
Design
Preclinical
Follow-up
60 min ischemia followed by 30 min reperfusion
Authors
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Adenosine receptor activation partially aids energy recovery in ischemic myocardium; leaves open its role in contractile recovery and human relevance.
Does interstitial adenosine mediate acute hibernation of guinea pig myocardium?
Activation of adenosine receptors aids in the recovery of cytosolic energy levels in moderately ischemic myocardium, though it is not the sole factor for postischemic contractile recovery.
Gao et al. (1995) studied Myocardial hibernation and ischaemia. Adenosine receptor antagonist (8-SPT) and ecto 5'-nucleotidase inhibitor vs. Untreated hearts was evaluated on Cytosolic energy level and postischaemic contractile recovery. Activation of adenosine receptors results in recovery of cytosolic energy level of moderately ischaemic working myocardium, but is not solely responsible for postischaemic contractile recovery.
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