June 1, 1995AJP Heart and Circulatory Physiology
Regional short-term myocardial hibernation in swine does not involve endogenous adenosine or KATP channels
Key result
In a swine model of short-term myocardial hibernation, neither endogenous adenosine elimination nor KATP channel blockade prevented the recovery of creatine phosphate or inotropic reserve.
Why the study?
Does elimination of endogenous adenosine or blockade of KATP channels prevent the development of short-term myocardial hibernation in a swine model of ischemia?
Population
22 enflurane-anesthetized swine with coronary inflow reduced to decrease regional myocardial work by 60-70%…
Comparison
Intracoronary adenosine deaminase or… vs Placebo-treated swine undergoing the same…
Design
Preclinical
Follow-up
90 minutes
Authors
Discussion
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Implication
Challenges presumed adenosine/KATP necessity in swine hibernation; leaves open mechanisms and clinical relevance.
Structured PICO
Does elimination of endogenous adenosine or blockade of KATP channels prevent the development of short-term myocardial hibernation in a swine model of ischemia?
P
Population
22 enflurane-anesthetized swine subjected to coronary inflow reduction to study short-term myocardial hibernation over 90 minutes of ischemia.
I
Intervention
Intracoronary adenosine deaminase (ADA) (n=7) or glibenclamide (n=7) during 90 min of ischemia, with intracoronary dobutamine infusion during the last 5 min
C
Comparator
Placebo-treated swine (n=8) undergoing the same ischemia protocol
O
Outcome
Recovery of myocardial creatine phosphate content, recruitable inotropic reserve (increase in myocardial work during dobutamine infusion), and absence of myocardial necrosissurrogate
Endogenous adenosine and KATP channel activation are not required for the development of short-term myocardial hibernation in a swine model.
Cite This Study
Schulz et al. (1995) studied Short-term myocardial hibernation (n=22). Adenosine deaminase (ADA) or glibenclamide vs. Placebo was evaluated on Creatine phosphate content recovery and myocardial work increase. In a swine model of short-term myocardial hibernation, neither endogenous adenosine elimination nor KATP channel blockade prevented the recovery of creatine phosphate or inotropic reserve.