Why the study?
Does dobutamine improve regional myocardial function in the presence of a critical coronary artery stenosis in a porcine model?
Population
8 pigs under 0.5% halothane anesthesia with a critical constriction applied to the left anterior descending…
Comparison
Intravenous dobutamine (2.5 and 5 μg·kg−1·min−1) vs Baseline function prior to dobutamine infusion…
Design
Preclinical
Authors
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Dobutamine response differs by coronary territory in this model; leaves open whether hibernation alters inotrope selection in patients.
Does dobutamine improve regional myocardial function in the presence of a critical coronary artery stenosis in a porcine model?
Inotropic stimulation with dobutamine does not improve regional myocardial function in territories supplied by a critically stenosed coronary artery, indicating the presence of myocardial hibernation.
Coetzee et al. (1990) studied this question.
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