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July 1, 1992AJP Heart and Circulatory Physiology

An animal model of chronic coronary stenosis resulting in hibernating myocardium

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Population

16 animals (7 selected for final review) undergoing instrumentation for coronary stenosis

Comparison

Reduction of maximum phasic flow velocity in the… vs Baseline (aerobic values)

Design

Preclinical

Follow-up

1 week of stenosis followed by 2 hours of reperfusion

Authors

HBHakki BölükogluAllegheny General HospitalALA. J. LiedtkeUniversity Hospital of BaselSNS. H. NellisPennsylvania State University

Discussion

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Implication

Provides viable animal model of hibernating myocardium without infarction; extends preclinical tools but leaves clinical translation open.

Structured PICO

P
Population
16 animals (7 selected for final review) undergoing instrumentation for coronary stenosis
I
Intervention
Reduction of maximum phasic flow velocity in the left anterior descending (LAD) coronary artery by 50% over 1 week
C
Comparator
Baseline (aerobic values)
O
Outcome
Regional shortening, metabolic determinations, and mitochondrial respirationsurrogate

A new experimental animal model of chronic coronary stenosis successfully replicates the mechanical and metabolic features of hibernating myocardium without causing gross infarction.

Cite This Study

Bölükoglu et al. (1992) studied this question.

synapsesocial.com/papers/6a71bb75fe4101aa97e0a9b8https://doi.org/10.1152/ajpheart.1992.263.1.h20
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dissociation of Regional Adaptations to Ischemia and Global Myolysis in an Accelerated Swine Model of Chronic Hibernating Myocardium2002 · 59 citations
  2. 2Cellular models of hibernating myocardium: implications for future research2001 · 6 citations
  3. 3Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and Oxygen Consumption at Rest2003 · 111 citations
  4. 4A nonsurgical porcine model of left ventricular dysfunction. Validation of myocardial viability using dobutamine stress echocardiography and positron emission tomography2000 · 5 citations
  5. 5Hibernating Myocardium2004 · 156 citations