What does this research mean for the field?

Ischemic or short-term hibernating myocardium exhibits a biphasic response to incremental dobutamine infusion, characterized by initial functional improvement at low doses followed by functional and metabolic deterioration at higher doses. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 15, 1995Circulation

Incremental Doses of Dobutamine Induce a Biphasic Response in Dysfunctional Left Ventricular Regions Subtending Coronary Stenoses

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Why the study?

Does incremental dobutamine infusion induce a biphasic response in regional wall thickening in ischemic or hibernating myocardium in a pig model?

Population

26 pigs in four groups: control, acute myocardial ischemia, short-term myocardial hibernation for 90…

Comparison

Incremental dobutamine infusion from 2.5 to 25… vs Control group of pigs with nonstenotic coronary…

Design

Preclinical

Authors

CCChunguang ChenTechnische Universität Dresden LLLi LiUniversity of Massachusetts Chan Medical School LCLiang Long ChenHartford Hospital

Discussion

Member takes

Implication

Biphasic dobutamine response in hibernating myocardium warrants interpretive caution; leaves optimal viability protocols open for clinical validation.

Structured PICO

Does incremental dobutamine infusion induce a biphasic response in regional wall thickening in ischemic or hibernating myocardium in a pig model?

Population

26 pigs in four groups: control (n=5), acute myocardial ischemia (n=7), short-term myocardial hibernation for 90 minutes (n=7), and short-term hibernation for 24 hours (n=7).

Intervention

Incremental dobutamine infusion from 2.5 to 25 micrograms.kg-1.min-1

Comparator

Control group of pigs with nonstenotic coronary artery receiving the same incremental dobutamine infusion

Outcome

Regional wall thickening, regional coronary flow, and metabolic response (lactate production, myocardial acidosis)surrogate

In a pig model, incremental dobutamine infusion induces a biphasic response in ischemic or hibernating myocardium, characterized by initial functional improvement followed by deterioration and metabolic acidosis at higher doses, providing mechanistic insight into dobutamine stress echocardiography.

Cite This Study

Chen et al. (1995) studied this question.

synapsesocial.com/papers/6a1a2dc00fc4dc4e42436bbd https://doi.org/10.1161/01.cir.92.4.756

Topics

Echocardiography

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Implication

Biphasic dobutamine response in hibernating myocardium warrants interpretive caution; leaves optimal viability protocols open for clinical validation.

Incremental Doses of Dobutamine Induce a Biphasic Response in Dysfunctional Left Ventricular Regions Subtending Coronary Stenoses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Incremental Doses of Dobutamine Induce a Biphasic Response in Dysfunctional Left Ventricular Regions Subtending Coronary Stenoses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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