Population
Isolated perfused guinea pig hearts
Comparison
Hypoxia, exogenous adenosine, and adenosine… vs Normoxia or absence of antagonists
Design
Preclinical
Authors
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Adenosine antagonism attenuates hypoxic AV delay in guinea pig hearts; leaves open clinical translation pending human studies.
Adenosine is the primary mediator of hypoxia-induced atrioventricular conduction delay in isolated guinea pig hearts, acting through adenosine receptors similar to those for exogenous adenosine.
Clemo et al. (1986) studied this question.
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