Why the study?
Does adenosine act via specific receptor mechanisms to produce neural stunning of sympathetic coronary innervation in dogs?
Does adenosine act via specific receptor mechanisms to produce neural stunning of sympathetic coronary innervation in dogs?
Adenosine produces neural stunning of sympathetic coronary innervation through a receptor-mediated mechanism requiring activation of both A1 and A2 receptor subtypes.
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Supports adenosine A1/A2 mediation of canine neural stunning; extends prior findings but leaves open human translation.
Abe et al. (1997) studied this question.
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