Key result
Acadesine administered during both cardioplegia and reperfusion significantly improved postischemic left ventricular developed pressure after 24 hours of reperfusion (117 vs 73 mm Hg; p<0.05).
Why the study?
Does acadesine improve contractile function and metabolite levels in a transplanted rat heart model of ischemia-reperfusion injury?
Population
Transplanted rat heart model subjected to 4 hours of global ischemia and transplanted into recipient rats.
Comparison
Acadesine administered during cardioplegia… vs Acadesine-free control (saline).
Design
Preclinical
Follow-up
Up to 24 hours of reperfusion
Authors
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Hypothesis-generating in rat transplant IRI model; does not support clinical use of acadesine.
Does acadesine improve contractile function and metabolite levels in a transplanted rat heart model of ischemia-reperfusion injury?
Absolute Event Rate: 117% vs 73%
p-value: p=<0.05
Acadesine provides sustained functional protection against ischemia-reperfusion injury in a transplanted rat heart model.
Galiñanes et al. (1992) studied Ischemia- and reperfusion-induced injury (n=64). Acadesine vs. Acadesine-free control (saline) was evaluated on Left ventricular developed pressure (LVDP) at 12 mm Hg of left ventricular end-diastolic pressure (LVEDP) after 24 hours of reperfusion (p=<0.05). Acadesine administered during both cardioplegia and reperfusion significantly improved postischemic left ventricular developed pressure after 24 hours of reperfusion (117 vs 73 mm Hg; p<0.05).
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