Key result
Reperfusion in a canine MI model progressively reduces relative territorial perfusion to ~55%.
Population
12 anesthetized dogs with left anterior descending coronary artery occluded for 90 min and then freely…
Design
Preclinical
Follow-up
4 hours
Authors
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May indicate progressive no-reflow despite vessel patency in MI; hypothesis-generating in canine model, requires human validation.
p-value: p=<0.05
Serial positron emission tomography with rubidium-82 demonstrates a progressive loss of infarct perfusion (no reflow) beginning 1 to 2 hours after initial restoration of blood flow despite patency of the infarct-related artery.
Jeremy et al. (1990) studied Myocardial infarction (n=12). Coronary occlusion and reperfusion vs. Normal circumflex artery region was evaluated on Relative perfusion in the left anterior descending artery territory after 4 hours of reperfusion (p=<0.05). In a canine model of myocardial infarction, relative perfusion in the reperfused territory progressively decreased from 97% at 5 minutes to 55% after 4 hours of reperfusion (p<0.05).
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