September 1, 1987Cardiovascular Research
Effect of early coronary artery reperfusion on infarct development in a model of low collateral flow
Key result
Early coronary reperfusion within 30 minutes reduces necrosis area ~54% versus permanent occlusion.
- 36.4% vs 78.6%
Why the study?
Collateral blood flow patterns after coronary artery occlusion and the potential for tissue salvage by reperfusion in a rat model with low collateral flow were not well characterised.
Does early coronary artery reperfusion reduce infarct size in a rat model of low collateral flow?
Population
Anaesthetised rats subjected to coronary artery occlusion
Comparison
20, 30, 40, or 60 min coronary occlusion plus 24 h reperfusion vs 24 h permanent occlusion
Design
Preclinical experimental study
Follow-up
24 h
Authors
Discussion
Loading...
Member takes
Overview
Confirms infarct size reduction with early reperfusion in low-collateral rat model; leaves open translation to human STEMI.
Structured PICO
Does early coronary artery reperfusion reduce infarct size in a rat model of low collateral flow?
P
Population
Anaesthetised rats subjected to varying durations of coronary occlusion followed by 24 hours of reperfusion or permanent occlusion.
I
Intervention
20, 30, 40, or 60 min of coronary occlusion followed by 24 h of reperfusion
C
Comparator
24 h of permanent coronary occlusion
O
Outcome
Area of necrosis as a percentage of the area at risk and transmural extent of the infarctsurrogate
Main Result
Absolute Event Rate: 36.4% vs 78.6%
Early coronary reperfusion in a rat model of low collateral flow significantly reduces infarct size, with tissue salvage occurring mainly in the midmyocardium and subepicardium.
Cite This Study
Hale et al. (1987) studied Coronary artery occlusion. Early coronary artery reperfusion vs. Permanent occlusion was evaluated on Area of necrosis as a percentage of the area at risk. Early coronary artery reperfusion up to 30 minutes after occlusion significantly decreased the area of necrosis compared with permanent occlusion (36.4% vs 78.6%).