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June 1, 1986Cardiovascular Research

Salvage of ischaemic myocardium by reperfusion: importance of collateral blood flow and myocardial oxygen demand during occlusion

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Why the study?

Does reperfusion after varying durations of coronary occlusion reduce the area of myocardial necrosis compared to permanent occlusion in a canine model?

Population

Open chest anaesthetised dogs undergoing left anterior descending coronary artery occlusion

Comparison

Reperfusion after 1, 2, 3, 4, or 6 hours of left… vs Permanent occlusion

Design

Preclinical

Follow-up

96 hours

Authors

KPKarin PrzyklenkMVMaria T. VivaldiFSFrederick J. Schoen

Discussion

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Overview

This preclinical study demonstrates that the salvage of ischemic myocardium by reperfusion is highly time-dependent and strongly influenced by collateral blood flow and myocardial oxygen demand.

Structured PICO

Does reperfusion after varying durations of coronary occlusion reduce the area of myocardial necrosis compared to permanent occlusion in a canine model?

P
Population
Open chest anaesthetised dogs undergoing left anterior descending coronary artery occlusion (n=8 per group, total n=48)
I
Intervention
Reperfusion after 1, 2, 3, 4, or 6 hours of left anterior descending coronary artery occlusion
C
Comparator
Permanent occlusion
O
Outcome
Area of necrosis quantified from histological sections and expressed as a percentage of occluded bed size (AN/OB) at 96 hours after occlusionsurrogate

This preclinical study demonstrates that the salvage of ischemic myocardium by reperfusion is highly time-dependent and strongly influenced by collateral blood flow and myocardial oxygen demand.

Cite This Study

Przyklenk et al. (1986) studied this question.

synapsesocial.com/papers/6a853f9daf90e4b27242eb96https://doi.org/10.1093/cvr/20.6.403
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