What question did this study set out to answer?

To determine how restoring blood flow at 2 versus 6 hours following circumflex coronary artery occlusion alters the final extent of histological myocardial infarction compared with permanent occlusion.

October 1, 1985AJP Heart and Circulatory Physiology

Effects of reestablishing blood flow on extent of myocardial infarction in conscious dogs

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Why the study?

Does reestablishing blood flow at 2 or 6 hours after occlusion reduce the extent of histological infarction in dogs with circumflex coronary artery occlusion?

Population

Chronically instrumented awake dogs with circumflex coronary artery occlusion

Comparison

Reestablishing blood flow at 2 hours and 6 hours… vs Permanent circumflex coronary artery occlusion

Design

Preclinical

Authors

RMRobert H. MurdockShafran Gastroenterology Center ACAlan ChuSecond Affiliated Hospital of Zhengzhou University MGMark GrubbUniversity of Nottingham

Discussion

Member takes

Implication

Reperfusion did not reduce overall LV infarct size in this canine model; leaves open layer-specific effects for translational research.

Key Points

To determine how restoring blood flow at 2 versus 6 hours following circumflex coronary artery occlusion alters the final extent of histological myocardial infarction compared with permanent occlusion.
Chronically instrumented conscious dogs were subjected to permanent circumflex coronary artery occlusion or occlusion followed by reperfusion at 2 or 6 hours.
Regional left ventricular myocardial blood flow was quantified across epicardial and endocardial layers using microsphere techniques to model predicted versus observed tissue necrosis.
Mean histological infarction was 21 +/- 13% of left ventricular weight in the permanent occlusion group, 19 +/- 10% in the 6-hour reperfusion group, and 13 +/- 12% in the 2-hour reperfusion group (differences not statistically significant overall).
Analysis stratified by ischemic blood flow tiers revealed significant tissue preservation across epicardial and endocardial layers in the 2-hour reperfusion group, but no significant preservation in the 6-hour group.
Reperfusion at 2 hours reduced infarction extent in most individual subjects, though salvage was not observed in select animals with very large initial ischemic zones.

Structured PICO

Does reestablishing blood flow at 2 or 6 hours after occlusion reduce the extent of histological infarction in dogs with circumflex coronary artery occlusion?

Population

Chronically instrumented awake dogs with circumflex coronary artery occlusion

Intervention

Reestablishing blood flow at 2 hours and 6 hours after circumflex coronary artery occlusion

Comparator

Permanent circumflex coronary artery occlusion

Outcome

Final extent of histological infarction (HI) as a percentage of left ventricular weightsurrogate

In a canine model, reperfusion at 2 hours, but not 6 hours, reduced histological infarction in specific myocardial layers and ischemic blood flow ranges, though overall left ventricular infarction extent was not significantly different.

Cite This Study

Murdock et al. (1985) studied this question.

synapsesocial.com/papers/6a76c50ef6749a0058ec3265 https://doi.org/10.1152/ajpheart.1985.249.4.h783

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Effects of reestablishing blood flow on extent of myocardial infarction in conscious dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of reestablishing blood flow on extent of myocardial infarction in conscious dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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