Myocardial infarction and remodeling in mice: effect of reperfusion
Why the study?
Does late reperfusion after coronary occlusion improve ventricular repair and function compared to permanent occlusion in mice?
Population
C57BL/6 mice undergoing experimental myocardial infarction
Comparison
2 hours of left anterior descending coronary… vs Permanent left anterior descending coronary…
Design
Preclinical
Follow-up
2 weeks
Authors
Discussion
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Implication
Late reperfusion may attenuate remodeling in murine MI; hypothesis-generating for clinical translation, which requires prospective trials.
Structured PICO
Does late reperfusion after coronary occlusion improve ventricular repair and function compared to permanent occlusion in mice?
P
Population
C57BL/6 mice undergoing experimental myocardial infarction
I
Intervention
2 hours of left anterior descending coronary artery occlusion followed by reperfusion (OR)
C
Comparator
Permanent left anterior descending coronary artery occlusion (PO) and sham-operated controls
O
Outcome
Anatomic and functional changes including infarct size, LV ejection velocity, filling velocity, ejection fraction, expansion ratio, and septal masssurrogate
Late reperfusion after myocardial infarction in mice reduces infarct expansion and septal hypertrophy, promoting recovery of ventricular function even when infarct size is not altered.
Cite This Study
Michael et al. (1999) studied this question.