Key result
Delayed reperfusion without myocardial salvage attenuated the increase in myocyte length in viable left ventricular tissue compared to permanent ligation (155 vs 167 microns, p=0.02).
Why the study?
Does delayed reperfusion following myocardial infarction attenuate structural remodeling in viable myocardium in a rat model?
Population
Rats with experimental myocardial infarction (n=31 total: 11 reperfused, 10 non-reperfused, 10 sham)
Comparison
Reperfusion 150 minutes after left coronary… vs Permanent ligation of left coronary vessels and…
Design
Preclinical
Follow-up
28 days
Authors
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May attenuate viable-myocardium hypertrophy post-MI without salvage in rats; leaves open clinical translation in humans.
Does delayed reperfusion following myocardial infarction attenuate structural remodeling in viable myocardium in a rat model?
Absolute Event Rate: 155% vs 167%
p-value: p=0.02
Delayed reperfusion after myocardial infarction in rats attenuates myocyte hypertrophy in viable myocardium despite no reduction in infarct size.
Kenneth McDonald (1997) studied Myocardial infarction (n=31). Reperfusion 150 minutes after ligation vs. Permanent ligation and sham-operated was evaluated on Myocyte length in viable, non-infarcted left ventricular tissue (microns) (p=0.02). Delayed reperfusion without myocardial salvage attenuated the increase in myocyte length in viable left ventricular tissue compared to permanent ligation (155 vs 167 microns, p=0.02).
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