Key result
Reperfusion after 30 or 60 minutes of coronary artery occlusion in mice significantly decreased infarct size as a percentage of the area at risk compared with permanent occlusion (68.6%).
Population
Mice (murine model of myocardial ischemia and reperfusion)
Comparison
Left anterior descending coronary artery… vs Permanent left anterior descending coronary…
Design
Preclinical
Authors
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Establishes murine ischemia-reperfusion model; leaves open translation to clinical reperfusion strategies.
This study establishes a murine model of myocardial ischemia and reperfusion, demonstrating that reperfusion after 30 or 60 minutes significantly reduces infarct size compared to permanent occlusion.
Michael et al. (1995) studied Myocardial ischemia and reperfusion (n=13). Coronary artery occlusion followed by reperfusion vs. Permanent occlusion was evaluated on Infarct size as a percentage of the area at risk (AAR). Reperfusion after 30 or 60 minutes of coronary artery occlusion in mice significantly decreased infarct size as a percentage of the area at risk compared with permanent occlusion (68.6%).
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