Key result
Precision LAD ligation cuts procedure time, controls infarct size, and improves mouse survival in MI models.
Why the study?
A simple and reproducible model of myocardial infarction and myocardial ischemia-reperfusion injury was needed for researchers.
Population
Mice
Design
Animal protocol description
Authors
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Refines murine MI modeling; leaves open clinical translation pending validation in larger species.
Lv et al. (2022) studied Myocardial infarction and myocardial ischemia-reperfusion injury. Precision ligation of the left anterior descending coronary artery (LAD) through micromanipulation was evaluated on Model accuracy, myocardial injury, myocardial systolic function, and infarct size. A customizable method using precision ligation of the LAD through micromanipulation reduces procedure duration, ensures controllable infarct size, and improves mouse survival in MI and MIRI models.
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