Key result
Reperfusion 12 hours after coronary occlusion significantly decreased the transmurality of necrosis compared to permanent occlusion (58.7% vs 83.8%; p<0.01) in a canine model.
Why the study?
Does reperfusion 12 hours after coronary occlusion improve myocardial salvage in a dog model of myocardial infarction?
Does reperfusion 12 hours after coronary occlusion improve myocardial salvage in a dog model of myocardial infarction?
Absolute Event Rate: 58.7% vs 83.8%
p-value: p=<0.01
Late reperfusion 12 hours after coronary occlusion significantly reduces the transmurality of necrosis and increases viable myocardium in a canine model.
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Hypothesis-generating for delayed reperfusion in canine MI; leaves open translation to human practice.
Kimura et al. (1998) studied Acute myocardial infarction (n=11). Reperfusion 12 hours after coronary occlusion vs. Permanent occlusion was evaluated on Transmurality of necrosis (p=<0.01). Reperfusion 12 hours after coronary occlusion significantly decreased the transmurality of necrosis compared to permanent occlusion (58.7% vs 83.8%; p<0.01) in a canine model.
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