Why the study?
Does reperfusion after 60 or 120 minutes of ischemia reduce infarct size in pig hearts without collateral circulation?
Population
15 pig hearts without collateral circulation
Comparison
Left anterior descending coronary artery… vs Left anterior descending coronary artery…
Design
Preclinical
Follow-up
8 hours
Authors
Loading...
Reperfusion at 60 minutes may yield extensive infarction in collateral-free hearts; leaves open optimal human timing thresholds.
Does reperfusion after 60 or 120 minutes of ischemia reduce infarct size in pig hearts without collateral circulation?
In a pig model without collateral circulation, reperfusion after 1 hour of ischemia still results in an 80% infarct area, suggesting that coronary reperfusion therapies must be performed within one hour of onset to significantly reduce infarct size.
Fujiwara et al. (1987) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: