Why the study?
Does the duration of ischemia before reperfusion affect the extent of contraction band necrosis and infarct size in a porcine heart model?
Population
25 porcine hearts without collateral circulation
Comparison
Left anterior descending coronary artery… vs Permanent occlusion (no reperfusion)
Design
Preclinical
Follow-up
8 hours
Authors
Loading...
Contraction band necrosis predominates with early reperfusion in porcine ischemia; leaves open whether targeting it reduces human infarct size.
Does the duration of ischemia before reperfusion affect the extent of contraction band necrosis and infarct size in a porcine heart model?
In a porcine model, contraction band necrosis is a major component of infarct size when reperfusion occurs after 1 hour of ischemia, suggesting protection against it might reduce infarct size.
Miyazaki et al. (1987) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: