Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 1989AJP Heart and Circulatory Physiology

A simple technique for occlusion and reperfusion of coronary artery in conscious rats

View Full Paper
Ask AI
Bookmark
Share

Population

Conscious rats

Comparison

Acute left coronary artery occlusion with… vs Permanent LCA occlusion (4 h)

Design

Preclinical

Follow-up

4 hours

Authors

NHNoriko HimoriTohoku UniversityAMAkio MatsuuraIchinomiya Municipal City Hospital

Discussion

Loading...

Member takes

Implication

Facilitates conscious rat studies of ischemia-reperfusion without anesthesia; leaves open translation to clinical settings.

Structured PICO

P
Population
Conscious rats
I
Intervention
Acute left coronary artery (LCA) occlusion (0.5 h) with reperfusion (3.5 h)
C
Comparator
Permanent LCA occlusion (4 h)
O
Outcome
Infarct size, plasma CPK concentration, mortality, and electromyocardiogram changessurrogate

A simple technique for coronary occlusion and reperfusion in conscious rats enables the study of ischemia-reperfusion injury without the confounding effects of anesthesia.

Cite This Study

Himori et al. (1989) studied this question.

synapsesocial.com/papers/6a73bf720f8808cba78de411https://doi.org/10.1152/ajpheart.1989.256.6.h1719
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of early coronary artery reperfusion on infarct development in a model of low collateral flow1987 · 48 citations
  2. 2Optimal Duration of Coronary Ligation and Reperfusion for Reperfusion Injury Study in a Rat Model.2016 · 6 citations
  3. 3Immediate functional recovery and avoidance of reperfusion injury with surgical revascularization of short-term coronary occlusion.1985 · 36 citations
  4. 4Coronary Reperfusion in Primates SERIAL ELECTROCARDIOGRAPHIC AND HISTOLOGIC ASSESSMENT1974 · 67 citations
  5. 5Coronary Collateral Regression in Conscious Dogs1990 · 19 citations