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December 1, 1999AJP Heart and Circulatory Physiology

Pharmacological manipulation of Ins(1,4,5)P3signaling mimics preconditioning in rabbit heart

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Why the study?

Does pharmacological manipulation of Ins(1,4,5)P3 signaling mimic ischemic preconditioning in reducing infarct size in isolated rabbit hearts?

Population

Isolated, buffer-perfused rabbit hearts and isolated fura 2-loaded rat cardiomyocytes

Comparison

Pharmacological manipulation of InsP3 signaling… vs No intervention and ischemic preconditioning alone

Design

Preclinical

Follow-up

2 hours (reflow)

Authors

AGAnne GysemberghUniversity of Southern CaliforniaSBStéphanie Barrère‐LemaireCentre National de la Recherche ScientifiqueCPChristophe PiotInterventional Cardiology

Discussion

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Implication

Supports Ins(1,4,5)P3 modulation as a cardioprotective target; leaves open translation from rabbit models to clinical practice.

Structured PICO

Does pharmacological manipulation of Ins(1,4,5)P3 signaling mimic ischemic preconditioning in reducing infarct size in isolated rabbit hearts?

P
Population
Isolated, buffer-perfused rabbit hearts and isolated fura 2-loaded rat cardiomyocytes
I
Intervention
Pharmacological manipulation of Ins(1,4,5)P3 signaling using D-myo-inositol-1,4,5-trisphosphate hexasodium salt (D-myo-Ins(1,4,5)P3) and 2-aminoethoxydiphenyl borate (2-APB), with or without ischemic preconditioning (PC)
C
Comparator
No intervention (control) and ischemic preconditioning (PC) alone
O
Outcome
Infarct size delineated by tetrazolium staining after 30-min coronary occlusion and 2 h reflowsurrogate

Pharmacological manipulation of Ins(1,4,5)P3 signaling mimics the cardioprotection achieved with ischemic preconditioning in rabbit hearts.

Cite This Study

Gysembergh et al. (1999) studied this question.

synapsesocial.com/papers/6a81a55eb5fee548463c7a03https://doi.org/10.1152/ajpheart.1999.277.6.h2458
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Suppression of Ventricular Arrhythmias During Ischemia-Reperfusion by Agents Inhibiting Ins(1,4,5)P<sub>3</sub>Release1995 · 81 citations
  2. 2Alpha-adrenoceptor stimulation with exogenous norepinephrine or release of endogenous catecholamines mimics ischemic preconditioning.1994 · 145 citations
  3. 3Is Calcium a Mediator of Infarct Size Reduction With Preconditioning in Canine Myocardium?1997 · 46 citations
  4. 4Different intracellular localization of inositol 1,4,5-trisphosphate and ryanodine receptors in cardiomyocytes.1993 · 112 citations
  5. 5Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.1992 · 119 citations