Why the study?
Does dipyridamole alter cellular adenosine release and interstitial adenosine levels in the myocardium?
Population
Preclinical model (specific animal or preparation not detailed in abstract, involves pericardial infusates)
Comparison
Dipyridamole vs Baseline/control state without dipyridamole
Design
Preclinical
Authors
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Supports interstitial adenosine in coronary hyperemia in animals; extends uptake-inhibition data but leaves clinical translation open.
Does dipyridamole alter cellular adenosine release and interstitial adenosine levels in the myocardium?
Dipyridamole increases interstitial adenosine levels by inhibiting uptake without altering cellular release, supporting the role of interstitial adenosine in active hyperemia.
Knabb et al. (1984) studied this question.
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