Why the study?
Does administration of dipyridamole and theophylline affect myocardial metabolism of cAMP and lactate in patients with coronary heart disease?
Population
16 patients (4 females, 12 males) ranging from 36 to 54 years with proven coronary heart disease.
Comparison
Dipyridamole 0.5 mg/kg body weight and… vs Baseline measurements at rest
Design
Case_series
Authors
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May link dipyridamole to ischemia via cAMP/lactate in CHD; hypothesis-generating and should not change practice.
Does administration of dipyridamole and theophylline affect myocardial metabolism of cAMP and lactate in patients with coronary heart disease?
Dipyridamole-induced myocardial ischemia and angina in patients with coronary heart disease correlate with myocardial release of cAMP and lactate.
Hombach et al. (1979) studied this question.
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