Why the study?
Does the combination of dipyridamole and ATP enhance coronary vasodilation in anesthetized dogs?
Population
20 anesthetized dogs (10 in group 1, 7 in group 2, 3 in group 3)
Comparison
Combination of ATP and dipyridamole vs ATP alone, dipyridamole alone, or other…
Design
Preclinical
Follow-up
20-minute infusion or 1 hour post-dose
Authors
Loading...
Synergistic coronary vasodilation occurs with the combination in dogs; leaves open translation to human coronary flow regulation.
Does the combination of dipyridamole and ATP enhance coronary vasodilation in anesthetized dogs?
Dipyridamole markedly enhances the coronary vasodilator action of ATP in a canine model.
Afonso et al. (1967) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: