Why the study?
Does dipyridamole dilate large coronary arteries and alter coronary resistance in conscious dogs?
Does dipyridamole dilate large coronary arteries and alter coronary resistance in conscious dogs?
Dipyridamole exerts potent dilatory effects on both coronary arterial resistance and large coronary arteries in conscious dogs, independent of reflex adrenergic activation but dependent on myocardial adenosine production.
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No clinical implications in humans; leaves open adenosine dependence of coronary dilation in conscious models.
Hintze et al. (1983) studied this question.
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