Different coronary vasodilators exert distinct regional effects on the coronary arterial tree, suggesting different contractile mechanisms between large conductance and small resistive coronary arteries.
Different vasodilators target distinct coronary vessel sizes; leaves open translation to human disease.
Using the isolated perfused heart preparation supported by a donor the effects of vasodilators on the large conductance artery were studied and were compared with those on the small resistive artery and arterioles. Nitroglycerin produced a preferential dilation of the large conductance artery, while dipyridamole produced a dilation only of the small resistive artery and arterioles. Among the "calcium antagonistic" vasodilators tested, only diltiazem produced a dilatation of the large conductance artery, verapamil and nifedipine producing a dilatation only of the small resistive artery and arterioles. These findings indicate that the mechanism of contraction of the large conductance artery is different from that of the small resistive artery and arterioles.
No takes yet. Share an insight, caveat, or question.
Takeda et al. (1977) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: