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November 30, 1999CirculationOpen Access

Classic Preconditioning Decreases the Harmful Accumulation of Nitric Oxide During Ischemia and Reperfusion in Rat Hearts

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Why the study?

Does preconditioning alter myocardial NO accumulation and postischemic function during ischemia/reperfusion in isolated rat hearts?

Population

Isolated working rat hearts

Comparison

Preconditioning protocols with or without NO… vs Nonpreconditioned hearts subjected to test…

Design

Preclinical

Follow-up

30 minutes of global no-flow ischemia and 15 minutes of…

Authors

CCCsaba CsonkaZSZoltán SzilvássyFFFerenc Fülöp

Discussion

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Overview

NO synthesis triggers preconditioning in rat hearts; extends mechanistic insight but leaves open clinical translation.

Structured PICO

Does preconditioning alter myocardial NO accumulation and postischemic function during ischemia/reperfusion in isolated rat hearts?

P
Population
Isolated working rat hearts
I
Intervention
Preconditioning protocols (3 intermittent periods of rapid pacing or no-flow ischemia of 5 minutes' duration each) with or without NO synthase inhibitor (N(G)-nitro-L-arginine [LNA] at 4.6 micromol/L or 46 micromol/L)
C
Comparator
Nonpreconditioned hearts subjected to test ischemia/reperfusion
O
Outcome
Myocardial NO content (assessed by electron spin resonance) and postischemic myocardial functionsurrogate

NO synthesis is necessary to trigger classic preconditioning, which subsequently protects the heart by attenuating harmful NO accumulation during ischemia/reperfusion.

Cite This Study

Csonka et al. (1999) studied this question.

synapsesocial.com/papers/6a7fb58ca3d55be9ef9fe8a8https://doi.org/10.1161/01.cir.100.22.2260
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs.1993 · 80 citations
  2. 2Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts1995 · 79 citations
  3. 3Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury1995 · 175 citations
  4. 4Evidence That Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Triggered by the Generation of Nitric Oxide1997 · 253 citations
  5. 5Does the Antiarrhythmic Effect of Ischemie Preconditioning in Rats Involve the L-Arginine Nitric Oxide Pathway?1995 · 50 citations