Population
66 female Sprague-Dawley rats
Comparison
Ischemic preconditioning vs Ischemia/reperfusion without preconditioning…
Design
Preclinical, randomly divided
Authors
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May implicate NO/cGMP pathway in cardioprotection; leaves open translation to human ischemic preconditioning.
In a rat model, nitric oxide and cGMP levels fluctuate during early phase myocardial ischemic preconditioning, suggesting they act as triggers and mediators of ischemic protection.
Han et al. (2008) studied this question.
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