Why the study?
Does inhibition of NO synthesis with L-NAME reduce infarct size in isolated rabbit hearts subjected to ischemia-reperfusion injury?
Population
Isolated rabbit hearts perfused at a constant flow rate of 35 mL/min, subjected to a model of coronary…
Comparison
NG-nitro-L-arginine methyl ester 30 mumol/L… vs Control (no L-NAME).
Design
Preclinical
Follow-up
180 minutes of reperfusion
Authors
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Should not change clinical practice; hypothesis-generating for adenosine-dependent cardioprotection in animal ischemia-reperfusion models.
Does inhibition of NO synthesis with L-NAME reduce infarct size in isolated rabbit hearts subjected to ischemia-reperfusion injury?
Inhibition of NO synthesis reduces infarct size in isolated rabbit hearts through an adenosine-dependent mechanism that shares a common pathway with ischemic preconditioning.
Woolfson et al. (1995) studied this question.
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