September 1, 1997Current Opinion in Cardiology
Ischemic preconditioning
Design
Review
Authors
Discussion
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Member takes
Implication
May guide development of cardioprotective agents; leaves open clinical translation pending prospective trials.
Structured PICO
I
Intervention
Ischemic preconditioning (repeated brief coronary occlusions)
O
Outcome
Myocardial resistance towards prolonged episodes of ischemia
Ischemic preconditioning provides acute and delayed cardioprotection against ischemia via adenosine receptors, ATP-sensitive potassium channels, and stress proteins, which may have future therapeutic applications.
Cite This Study
Schwarz et al. (1997) studied this question.