July 1, 1999Current Opinion in Cardiology
Clinical effects of ischemic preconditioning
Key result
Ischemic preconditioning and preconditioning mimetics demonstrate potential cardioprotective effects in patients with coronary artery disease, though further clinical research is required.
Population
Human patients with coronary artery disease and chronic myocardial ischemia
Design
Review
Authors
Discussion
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Implication
Potential cardioprotective effects in CAD should not yet guide therapy; leaves open validation in prospective trials.
Structured PICO
P
Population
Human patients with coronary artery disease and chronic myocardial ischemia
I
Intervention
Ischemic preconditioning (e.g., repeated balloon inflations, angina before acute myocardial infarction) and preconditioning mimetics (adenosine, adenosine receptor agonists, adenosine triphosphate-sensitive potassium channel openers)
O
Outcome
Cardioprotective effect (reduction of infarct size and better clinical outcome)
Ischemic preconditioning and its pharmacological mimetics offer potential cardioprotective strategies for patients with coronary artery disease, though certain drugs like sulfonylureas may counteract these effects.
Limitations
- Further research is required before preconditioning mimetics could be used for therapy in patients with chronic myocardial ischemia.
- Possible antipreconditioning effects of several drugs, e.g., sulfonylurea drugs, have to be considered in the treatment of patients with coronary artery disease.
Cite This Study
Schwarz et al. (1999) conducted a review in Coronary artery disease. Ischemic preconditioning and preconditioning mimetics was evaluated. Ischemic preconditioning and preconditioning mimetics demonstrate potential cardioprotective effects in patients with coronary artery disease, though further clinical research is required.