Why the study?
Does PDK4 inhibition increase glucose uptake and alleviate myocardial ischemia-reperfusion injury in preclinical models?
Does PDK4 inhibition increase glucose uptake and alleviate myocardial ischemia-reperfusion injury in preclinical models?
Inhibition of PDK4 stimulates glucose oxidation and uptake, offering a potential therapeutic approach to alleviate myocardial ischemia-reperfusion injury.
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Impaired post-reperfusion glucose uptake may limit metabolic recovery; leaves open whether targeting transport improves human I/R outcomes.
Li et al. (2017) studied this question.
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