Key result
In normal dogs, when arterial lactate concentration was raised above 4.5 mmol/L, 87% of the total substrate oxidized by the myocardium was lactate, even in the presence of high glucose or FFA.
Why the study?
Does the normal dog heart preferentially utilize lactate over glucose or free fatty acids when arterial lactate levels are elevated?
Population
Normal dogs under chloralose anaesthesia breathing spontaneously
Design
Preclinical
Authors
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Lactate preference in normal canine hearts extends substrate data; leaves open translation to human myocardium or disease.
Does the normal dog heart preferentially utilize lactate over glucose or free fatty acids when arterial lactate levels are elevated?
In normal dogs, the myocardium preferentially utilizes lactate for energy production over glucose or free fatty acids when arterial lactate levels are elevated.
Drake et al. (1980) studied Normal myocardium. Intravenous Sodium L-Lactate infusion was evaluated on Lactate oxidised as a percentage of total substrate. In normal dogs, when arterial lactate concentration was raised above 4.5 mmol/L, 87% of the total substrate oxidized by the myocardium was lactate, even in the presence of high glucose or FFA.
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