Population
Isolated rabbit hearts (normal myocardium)
Comparison
2.5 mM [3-13C]lactate or [3-13C]pyruvate with or… vs Comparison between lactate and pyruvate, with or…
Design
Preclinical
Authors
Loading...
Requires caution in 13C-NMR cardiac flux analyses using glutamate; leaves open redox-state effects in intact hearts.
In isolated rabbit hearts, the equilibrium between alpha-ketoglutarate and glutamate is sensitive to cytosolic redox state rather than PDH activation, impacting 13C-NMR metabolic analyses.
Lewandowski et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: