Population
Isolated hearts from male Sprague-Dawley rats
Design
Preclinical
Follow-up
5-115 min
Authors
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Supports separate nonexchanging lactate pool in rat hearts; leaves open relevance to human cardiac metabolism.
In isolated rat hearts, differences in steady-state enrichment between lactate and alanine suggest a separate nonexchanging pool of lactate rather than cytosolic compartmentation of pyruvate.
Chatham et al. (1996) studied this question.
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