Population
Isolated rat hindleg preparation, electrically prestimulated to partially deplete muscle glycogen
Comparison
Perfusion with medium containing glucose and/or… vs Different perfusion conditions
Design
Preclinical
Authors
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Warrants caution against clinical extrapolation from rat hindlimb; leaves open human relevance of lactate turnover in insulin action.
In the perfused rat hindlimb, there is extensive lactate turnover without net uptake, and pyruvate is incorporated into glycogen without carbon randomization.
Shiota et al. (1984) studied this question.
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