January 15, 1983Biochemical JournalOpen Access

Metabolic compartmentation of pyruvate in the isolated perfused rat heart

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Population

Isolated rat hearts

Design

Preclinical

Authors

Discussion

Supports two-pool pyruvate model in rodent heart; leaves open translation to human myocardium.

Population

Isolated rat hearts

Intervention

Perfusion with [1-14C]pyruvate, [1-14C]lactate, or [3,4-14C]glucose via once-through Langendorff technique

Outcome

Specific radioactivities of pyruvate, lactate, and alaninesurrogate

This preclinical study demonstrates the existence of two distinct cytosolic functional pyruvate pools in the isolated rat heart.

Peuhkurinen et al. (1983) studied this question.

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