March 18, 2004NMR in BiomedicineOpen Access

Compartmentation of glycolysis and glycogenolysis in the perfused rat heart

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Population

Isolated perfused rat hearts previously depleted of myocardial glycogen

Design

Preclinical

Authors

NANick AnousisThe University of Texas at Dallas RCRui A. CarvalhoCardio-Oncology PZPiyu ZhaoThe University of Texas at Dallas

Discussion

Member takes

Implication

Hypothesis-generating for glycolytic compartmentation in intact heart; leaves open relevance to human cardiac metabolism.

Structured PICO

Population

Isolated perfused rat hearts previously depleted of myocardial glycogen

Intervention

Perfusion with 5.5 mm [U-(13)C]glucose plus 50 mU/mL insulin, followed by [1-(13)C]glucose and stimulation with glucagon (1 microg/ml)

Outcome

Estimates of pyruvate derived from glucose vs glycogen and acetyl-CoA derived from glycolytic vs glycogenolytic pyruvate using (13)C NMR isotopomer analysissurrogate

This preclinical study provides evidence for functional compartmentation of glycolysis and glycogenolysis in the intact rat heart using (13)C NMR isotopomer analysis.

Cite This Study

Anousis et al. (2004) studied this question.

synapsesocial.com/papers/6a86b14fc7caab105a153fbb https://doi.org/10.1002/nbm.860

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Compartmentation of glycolysis and glycogenolysis in the perfused rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Compartmentation of glycolysis and glycogenolysis in the perfused rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider