April 1, 1999Cardiovascular ResearchOpen Access

Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics

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Why the study?

Does mitochondrial metabolism of pyruvate improve cardiac function and energetics in isolated guinea-pig hearts?

Structured PICO

Does mitochondrial metabolism of pyruvate improve cardiac function and energetics in isolated guinea-pig hearts?

Population

Isolated working guinea-pig hearts

Intervention

2.5 mM pyruvate added to 0.2 mM octanoate, with or without 0.6 mM alpha-Cyano-3-hydroxycinnamate (COHC) to selectively inhibit mitochondrial pyruvate uptake

Comparator

Pyruvate-free control hearts (0.2 mM octanoate alone)

Outcome

Left ventricular stroke work, power, mechanical efficiency, and cytosolic ATP phosphorylation potentialsurrogate

Mitochondrial metabolism of pyruvate, rather than just cytosolic oxidation, is essential for its positive inotropic and energetic effects in the heart.

Discussion

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Implication

Mitochondrial pyruvate metabolism is essential for cardiac energetics; leaves open translation to human HF therapies.

Cite This Study

Robert T. Mallet (1999) studied this question.

synapsesocial.com/papers/6a7944f114b028facf0daa4f https://doi.org/10.1016/s0008-6363(98)00300-9

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Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics

Structured PICO

Discussion

Implication

Cite This Study

Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider