Why the study?
Does pyruvate or butyrate infusion improve myocardial high-energy phosphate metabolism in anesthetized dogs during high workstates?
Does pyruvate or butyrate infusion improve myocardial high-energy phosphate metabolism in anesthetized dogs during high workstates?
Supplemental pyruvate, but not butyrate, attenuates the reduction of myocardial PCr/ATP during high workstates in anesthetized dogs, suggesting carbon substrate availability is not the sole cause of HEP reduction.
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Does not support clinical pyruvate use in high-work states; leaves open substrate-specific HEP effects in animal models.
Ochiai et al. (2001) studied this question.
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