Population
Anaesthetized pigs
Comparison
High cardiac workload induced by dobutamine for… vs Control conditions
Design
Preclinical
Follow-up
15 min
Authors
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Findings in animal hearts warrant no clinical change in inotrope use; leaves open PDH and CAC mechanisms as therapeutic targets in human HF.
During high cardiac workload, increased flux through PDH is regulated by enzyme activation and partially controlled by fatty acid oxidation inhibition, alongside an expansion of 4-carbon CAC intermediates.
Sharma et al. (2004) studied this question.
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