December 22, 2006The Journal of PhysiologyOpen Access

Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs

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Population

Anaesthetized pigs

Comparison

Abrupt increase in cardiac workload for 5 min… vs Sham treatment

Design

Preclinical

Follow-up

5 min

Authors

LZLufang ZhouThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute MCMarco E. CabreraThe University of Texas Rio Grande Valley HHHazel HuangUniversity of Washington

Discussion

Member takes

Implication

Caution against clinical translation from porcine data; leaves open NADH redox mechanisms in human cardiac workload transitions.

Structured PICO

Population

Anaesthetized pigs

Intervention

Abrupt increase in cardiac workload for 5 min with dobutamine infusion and aortic constriction (a third group also had fatty acid oxidation blocked by 75%)

Comparator

Sham treatment

Outcome

Changes in NADH/NAD+ ratio, ATP and ADP concentrations, and substrate metabolism activationsurrogate

In a porcine model, the transition to high cardiac workload rapidly activates substrate oxidation and increases the NADH/NAD+ ratio independently of fatty acid oxidation.

Cite This Study

Zhou et al. (2006) studied this question.

synapsesocial.com/papers/6a6fee4b2163a0a01bc42952 https://doi.org/10.1113/jphysiol.2006.123828

View Full Paper

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Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider