Key result
Computational modeling of an abrupt increase in cardiac energy expenditure showed a transient increase in cytosolic and mitochondrial NADH/NAD+ by 40% and 20% during the first minutes.
Population
Computational model of cardiac metabolism
Comparison
Simulation of an abrupt increase in energy… vs Resting state / low work state
Design
Preclinical
Authors
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Hypothesis-generating for parallel metabolic activation in acute cardiac stress; leaves open translation to human physiology.
Computational modeling supports the concept of parallel activation of metabolic processes generating reducing equivalents during an abrupt increase in cardiac energy expenditure.
Zhou et al. (2006) studied cardiac metabolism during increased energy expenditure. abrupt increase in energy expenditure vs. resting values was evaluated on cytosolic and mitochondrial NADH/NAD+ ratio. Computational modeling of an abrupt increase in cardiac energy expenditure showed a transient increase in cytosolic and mitochondrial NADH/NAD+ by 40% and 20% during the first minutes.
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