June 1, 1987Journal of Biological ChemistryOpen Access

Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.

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Why the study?

Does pyruvate perfusion improve cardiac contractile function and high energy phosphate metabolism compared to glucose in the isolated guinea pig heart?

Structured PICO

Does pyruvate perfusion improve cardiac contractile function and high energy phosphate metabolism compared to glucose in the isolated guinea pig heart?

Population

Isovolumic guinea pig heart model

Intervention

Perfusion with 10 mM pyruvate

Comparator

Perfusion with 16 mM glucose

Outcome

Cardiac contractile function (maximum left ventricular developed pressure), high energy phosphate metabolites (PCr, PCr/Pi ratio), and myocardial oxygen consumptionsurrogate

Pyruvate augments myocardial contractile performance and favorably alters high energy phosphate metabolism compared to glucose in the isolated perfused heart.

Discussion

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Implication

Hypothesis-generating for pyruvate in myocardial energetics; leaves open clinical translation pending in vivo validation.

Cite This Study

Zweíer et al. (1987) studied this question.

synapsesocial.com/papers/6a71f15d78a11c550e0bdf69 https://doi.org/10.1016/s0021-9258(18)47519-9

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Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.

Structured PICO

Discussion

Implication

Cite This Study

Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider